| 摘要 |
The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒC 15 H 17 NO 2
Mr = 243.30
Orthorhombic
Pca2 1
a = 31.501 (4) A
b = 9.5280 (10) A
c = 17.906 (2) A
Z=16
the process comprising the process steps of:
a) dissolving agomelatine in a water-miscible solvent to obtain a solution,
b) adding the solution to water having a temperature of 30°C or below, whereby crystals of the polymorph form I of agomelatine are formed,
c) isolating the crystals of the polymorph form I of agomelatine and
d) optionally drying the isolated crystals of the polymorph form I of agomelatine.
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