发明名称 |
COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PROTEIN FORMULATIONS |
摘要 |
Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes. |
申请公布号 |
EP1858532(A4) |
申请公布日期 |
2011.05.11 |
申请号 |
EP20060720199 |
申请日期 |
2006.02.02 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
BALASUBRAMANIAN, SATHYAMAGALAM;STRAUBINGER, ROBERT, M.;RAMANI, KARTHIK;PUROHIT, VIVEK, S. |
分类号 |
A61K35/14;A61K9/127;A61K38/17;A61K38/37;C07K14/775 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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