发明名称 |
Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)amine |
摘要 |
<p>The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonyl amide hydrochloride, wherein this compound is prepared directly from the chloromethyl alcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.</p> |
申请公布号 |
EP2319824(A2) |
申请公布日期 |
2011.05.11 |
申请号 |
EP20100185688 |
申请日期 |
2000.12.22 |
申请人 |
AMPAC FINE CHEMICALS LLC |
发明人 |
MALIK, ASLAM, A.;PALANDOKEN, HASAN;STRINGER, JOY, A.;CARLSON, ROLAND, P.;LEACH, JOHN;ARCHIBALD, THOMAS, G.;MIOTKE, ROBERT, G. |
分类号 |
C07C209/08;C07C269/06;C07C271/20;C07C303/40;C07C311/18 |
主分类号 |
C07C209/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|