| 发明名称 |
Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
| 摘要 |
The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.
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| 申请公布号 |
US7939677(B2) |
申请公布日期 |
2011.05.10 |
| 申请号 |
US20100872438 |
申请日期 |
2010.08.31 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
BHAT BALKRISHEN;DANDE PRASAD;PRAKASH THAZHA P.;ALLERSON CHARLES;SWAYZE ERIC E.;GRIFFEY RICHARD H. |
| 分类号 |
C07D409/04;A61K31/675;A61K48/00;C12N15/113;C12P21/04;C12Q1/68;G01N33/53 |
主分类号 |
C07D409/04 |
| 代理机构 |
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