发明名称 |
[1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITH CYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR |
摘要 |
The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidenediamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.(I) |
申请公布号 |
UA94398(C2) |
申请公布日期 |
2011.05.10 |
申请号 |
UA20070010139 |
申请日期 |
2006.02.08 |
申请人 |
ABBOTT HEALTHCARE PRODUCTS B.V. |
发明人 |
VEENSTRA ROELOF W.;KEIZER HISKIAS G.;PRAS-RAVES MARIA L.;VAN VLIET BERNARD J.;VAN SCHARRENBURG GUSTAAF J.M. |
分类号 |
C07D285/01;A61K31/425;A61K31/427;A61P25/28;C07D401/12;C07D403/12 |
主分类号 |
C07D285/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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