发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF ANGIOGENESIS IN PATHOLOGICAL LESIONS |
摘要 |
Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration, and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-.gamma. (IFN-.gamma.), Tumor Necrosis Factor .alpha.(TNF.alpha.) or Tissue Factor protein (which may be truncated). |
申请公布号 |
CA2399866(C) |
申请公布日期 |
2011.05.10 |
申请号 |
CA20012399866 |
申请日期 |
2001.02.22 |
申请人 |
PHILOGEN S.R.L. |
发明人 |
ZARDI, LUCIANO;NERI, DARIO;CARNEMOLLA, BARBARA;NILSSON, FREDRIK;TARLI, LORENZO;BORSI, LAURA;HALIN, CORNELIA |
分类号 |
A61K39/395;A61K47/48;A61P9/00;A61P35/00;C07K14/475;C07K14/525;C07K14/54;C07K14/55;C07K14/57;C07K14/705;C07K16/18;C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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