发明名称 PHARMACEUTICAL COMPOSITIONS CONTAINING THE ENZYME CYPROSIN, AN ASPARTIC PEPTIDASE FROM CYNARA CARDUNCULUS AND ITS INCLUSION IN ANTITUMOUR FORMULATIONS
摘要 An aspect of the present invention is the use of a preparation containing a phytepsin, more specifically a cyprosin, containing the heterodimer, its N-terminal pro-peptide, the mature N-terminal peptide, and mature C-terminal peptide, as well as other precursor species, processing products, and aggregate species, either isolated or in any combinations of the former, native, extracted and partially purified from flowers of Cynara cardunculus, or recombinant, extracted from the supernatant from a culture of Saccharomyces cereviseae genetically modified for the heterologous production of cyprosin, for therapeutic applications more precisely for its use as an antitumor agent.
申请公布号 US2011104286(A1) 申请公布日期 2011.05.05
申请号 US20080680530 申请日期 2008.11.28
申请人 SOARES PAIS MARIA SALOME;DE SOUSA SAMPAIO PEDRO NUNO;GANCHAS SOARES RITA ISABEL;BAPTISTA COELHO MARIA CONSTANCA;SILVA SANTOS JORGE MIGUEL;ESTILITA MONTEIRO DA CRUZ PEDRO;SOARES DA CRUZ HELDER JOAQUIM 发明人 SOARES PAIS MARIA SALOME;DE SOUSA SAMPAIO PEDRO NUNO;GANCHAS SOARES RITA ISABEL;BAPTISTA COELHO MARIA CONSTANCA;SILVA SANTOS JORGE MIGUEL;ESTILITA MONTEIRO DA CRUZ PEDRO;SOARES DA CRUZ HELDER JOAQUIM
分类号 A61K38/48;A61K9/14;A61P1/00;A61P9/00;A61P31/14;A61P35/00;B82Y5/00;C12N9/50;C12N9/96 主分类号 A61K38/48
代理机构 代理人
主权项
地址