发明名称 |
VERFAHREN ZUR BEHANDLUNG UND PRÄVENTION VON KOLITIS, AN DER IL-13 UND NK-T ZELLEN BETEILIGT SIND |
摘要 |
<p>A method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity. The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
The substance can be an anti-V±14J±281 antibody fragment, an anti-V±24J±18 antibody fragment, an anti-CD1 antibody fragment that inhibits antigen-presentation to NK-T cells or an anti-IL-13 or an anti-IL-13R± antibody fragment that inhibits IL-13 activity.</p> |
申请公布号 |
DE60239566(D1) |
申请公布日期 |
2011.05.05 |
申请号 |
DE2002639566 |
申请日期 |
2002.06.14 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL, BOSTON;GOVERNMENT OF THE UNITED STATES OF AMERICA |
发明人 |
STROBER, WARREN;FUSS, IVAN J.;HELLER, FRANK;BLUMBERG, RICHARD |
分类号 |
G01N33/50;G06G7/48;A61K38/17;A61K39/395;A61K45/00;A61P1/00;A61P1/04;A61P37/06;C07K14/715;C07K16/24;C07K16/28;C12Q1/02;G01N33/15;G01N33/68;G06G7/58 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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