发明名称 METHOD FOR PREPARATION OF MONTELUKAST ACID IN IONIC LIQUID MEDIUM
摘要 The present invention relates to a method for preparing Montelukast acid or its sodium salt by reacting a thiol compound with a Montelukast intermediate in the presence of a base in a medium comprising an ionic liquid compound. In accordance with the inventive method, highly pure Montelukast acid or its sodium salt, which is advantageously used as a raw material in the preparation of Montelukast, a leukotriene antagonist, can be easily prepared in a high yield.
申请公布号 US2011105757(A1) 申请公布日期 2011.05.05
申请号 US20080674118 申请日期 2008.10.01
申请人 HANMI PHARM. CO., LTD. 发明人 PARK CHUL-HYUN;PARK EUN-JU;KIM CHOONG-HAHN;JANG SUK MAN;LIM EUN JUNG;CHANG YOUNG KIL;LEE GWAN SUN;LEE JAEHEON
分类号 C07D215/14 主分类号 C07D215/14
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