| 摘要 |
Un compuesto o sal farmacéuticamente aceptable del mismo, en el que el compuesto es: 9-ciclopropil-8-metoxi-7-(4-(piperidin-1-ilmetil)fenil)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-8-metoxi-7-(2-metilpiridin-4-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-8-metoxi-7-(1,2,3,4-tetrahidroisoquinolin-6-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-8-metoxi-7-(6-metilpiridin-3-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-8-metoxi-7-((R)-1-metilisoindolin-5-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(isoindolin-5-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-8-metoxi-7-(1,2,3,4-tetrahidroisoquinolin-6-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-8-metoxi-7-(2-metil-1,2,3,4-tetrahidroisoquinolin-6-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-8-metoxi-7-(2-metil-1,2,3,4-tetrahidroisoquinolin-6-il)isotiazolo[5,4-b]quinolin-3,4(2H, 9H)-diona; 7-(3-amino-4-fluorofenil)-9-ciclopropil-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-8-metoxi-7-(2-metilpiridin-4-il)isotiazolo[5,4b]quinolin-3,4(2H,9H)-diona; O-metil oxima del (E)-4-(9-ciclopropil-6-fluoro-3,4-dioxo-2,3,4,9-tetrahidroisotiazolo[5,4-b]quinolin-7-il)picolinaldehído; 9-ciclopropil-6-fluoro-7-(2-(hidroximetil)piridin-4-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona, 9-ciclopropil-6-fluoro-7-(6-fluoropiridin-3-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(2-fluoropiridin-3-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(2-fluoropiridin-4-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-7-(4-(hidroximetil)fenil)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-7-(3-hidroxifenil)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 7-(4-aminofenil)-9-ciclopropil-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 7-(4-amino-3,5-dimetilfenil)-9-ciclopropil-6-fluoro-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 7-(4-amino-3,5-dimetilfenil)-9-ciclopropil-6-fluoroisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(4-hidroximetil)fenil)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-7-(2-fluoropiridin-4-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(2-metilpiridin-4-il)isotiazolo[5,4-b][1,8]naftiridin-3,4(2H,9H)-diona; 9-ciclopropil-7-(2,6-dimetilpiridin-4-il)-6-fluoroisotiazolo[5,4-b][1,8]naftiridin-3,4(2H,9H)-diona; 9-ciclopropil-8-metoxi-7-(piridin-3-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-7-(isoquinolin-6-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 5-(9-ciclopropil-6-fluoro-3,4-dioxo-2,3,4,9-tetrahidroisotiazolo[5,4-b]quinolin-7-il)nicotinonitrilo; 5-(9-ciclopropil-8-metoxi-3,4-dioxo-2,3,4,9-tetrahidroisotiazolo[5,4-b]quinolin-7-il)nicotinonitrilo; 5-(9-ciclopropil-6-fluoro-8-metoxi-3,4-dioxo-2,3,4,9-tetrahidroisotiazolo[5,4-b]quinolin-7-il)nicotinonitrilo; 9-ciclopropil-7-(6-fluoro-2-metilpiridin-3-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(6-fluoro-2-metilpiridin-3-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-7-(2,6-dimetilpiridin-3-il)-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(piridin-4-il)isotiazolo[5,4-b][1,8]naftiridin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(6-metilpiridin-3-il)isotiazolo[5,4-b][1,8]naftiridin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(piridin-3-il)isotiazolo[5,4-b][1,8]naftiridin-3,4(2H,9H)-diona; 7-(4-(aminometil)fenil)-9-ciclopropil-6-fluoroisotiazolo[5,4,b][1,8]naftiridin-3,4(2H,9H)-diona; 9-cilopropil-7-(2,6-difluoropiridin-3-il)-8-metoxisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; 9-ciclopropil-6-fluoro-7-(3-hidroxifenil)-8-metoxiisotiazolo[5,4b]quinolin-3,4(2H,9H)-diona; 7-(4-aminofenil)-9-ciclopropil-6-fluoro-8-metoxiisotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona; o 9-ciclopropil-6-fluoro-8-metoxi-7-(piridin-3-il)isotiazolo[5,4-b]quinolin-3,4(2H,9H)-diona.
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