METHOD FOR PRODUCING ANTIGEN-SPECIFIC B CELL POPULATION

摘要

Disclosed is a method for producing an antigen-specific B cell population which contains IgG-positive B cells that are specific to a particular antigen. The production method comprises a process in which IgG-positive B cells are cultured together with the particular antigen in the presence of IL-21, while providing the IgG-positive B cells with stimulation through CD40, BAFF receptor and Fas, and antigen-specific B cells that are specific to the particular antigen are selected, thereby obtaining the antigen-specific B cell population which contains IgG-positive B cells that are specific to the particular antigen.