发明名称 |
DRUG RESPONSE MARKERS |
摘要 |
The present invention relates to a method for predicting the response of a disease in a subject, preferably a human, to a drug providing 6-mercaptopurine, the method comprising the step of: (i) determining the presence or absence of a variant allele at a polymorphic site in a human leucocyte antigen (HLA)-G gene wherein the presence of said variant allele at said polymorphic site is indicative of clinical response or tolerance to said drug. The invention also provides a method of treating a subject suffering from a condition that would benefit from a drug providing 6-mercaptopurine.
|
申请公布号 |
US2011105538(A1) |
申请公布日期 |
2011.05.05 |
申请号 |
US20090921929 |
申请日期 |
2009.03.13 |
申请人 |
GUY'S & ST THOMAS'S NHS FOUNDATION TRUST |
发明人 |
MARINAKI ANTHONY M.;SANDERSON JEREMY DAVID;BABURAJAN BIJAY KAKKANT |
分类号 |
A61K31/52;A61P1/00;A61P3/10;A61P11/06;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P35/02;C12Q1/68 |
主分类号 |
A61K31/52 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|