发明名称 |
Binding domain-immunoglobulin fusion proteins |
摘要 |
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications. |
申请公布号 |
EP2316951(A1) |
申请公布日期 |
2011.05.04 |
申请号 |
EP20100182383 |
申请日期 |
2002.01.17 |
申请人 |
TRUBION PHARMACEUTICALS, INC. |
发明人 |
LEDBETTER, JEFFREY A.;HAYDEN-LEDBETTER, MARTHA |
分类号 |
C12N15/09;C12N15/62;A61K38/00;A61K38/16;A61K39/00;A61K39/395;A61P3/10;A61P5/14;A61P21/04;A61P25/00;A61P29/00;A61P35/00;A61P37/06;C07H21/04;C07K16/28;C07K16/30;C07K16/42;C07K16/44;C07K19/00;C12N5/10;C12N15/00;C12N15/13;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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