| 摘要 |
<p>The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.</p> |
| 申请人 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH);EBERHARD KARLS UNIVERSITAET TUEBINGEN;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
GASSER, THOMAS, PROF., DR.;HERZIG, PETRA (GEB. LEITNER);ASMUS, DR. FRIEDRICH;PATENGE, NADJA;MEITINGER, PROF. DR. THOMAS;STROM, PD DR. TIM MATTHIAS;BISKUP, DR. SASKIA;ZIMPRICH, DR. ALEXANDER;FARRER, MATTHEW;KACHERGUS, JENNIFER;LINCOLN, SARAH J.;HULIHAN, MARY;WSZOLEK, ZIBIGNIEW;UITTI, RYAN;UEFFING, DR. MARIUS;KREMMER, DR. ELISABETH;GLOECKNER, DR. CHRISTIAN JOHANNES |
