发明名称 |
THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS |
摘要 |
A series of thieno[2,3-b]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fused bicyclic ring system, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions. |
申请公布号 |
EP2315768(A1) |
申请公布日期 |
2011.05.04 |
申请号 |
EP20090766115 |
申请日期 |
2009.06.12 |
申请人 |
UCB PHARMA, S.A. |
发明人 |
JOHNSON, JAMES, ANDREW;BROOKINGS, DANIEL, CHRISTOPHER;LANGHAM, BARRY, JOHN;NEUSS, JUDI, CHARLOTTE;THORNE, JOANNA, RACHEL |
分类号 |
C07D519/00;C07D495/04 |
主分类号 |
C07D519/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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