| 摘要 |
A process for synthesis of androstane 17-&bgr; carbothioic acid is provided. The process includes mixing an androstane 17-&bgr; carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-&bgr; carbothioic acid, wherein the androstane 17-&bgr; carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.
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