发明名称 |
Poly(Propargyl-L-Glutamate) and Derivatives Thereof |
摘要 |
A process of the present invention is directed toward conducting highly selective, high yield post-polymerization reactions on polypeptides to prepare functionalized polypeptides. In certain embodiments, the polypeptides can be prepared by ring opening polymerization of N-carboxyanhydrides. In certain embodiments, the post-polymerization reaction is a “click chemistry” reaction. In certain embodiment, the “click chemistry” reaction is a triazole-forming reaction involving an alkyne on the polypeptide and an azide.
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申请公布号 |
US2011097419(A1) |
申请公布日期 |
2011.04.28 |
申请号 |
US20090607592 |
申请日期 |
2009.10.28 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
HAMMOND PAULA T.;ENGLER AMANDA C.;LEE HYUNG-IL |
分类号 |
C08F126/06;A61K9/14;A61K31/7105;C07D263/44;C08F38/00;C08G16/00 |
主分类号 |
C08F126/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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