TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS.

摘要

The invention relates to antibacterial compounds of formula (I) wherein “-----” is a bond or is absent, V is CH, CR ⁶ or N; R ⁰ is H or, if “-----” is a bond, may also be alkoxy; R ¹ is notably H or halogen; U is CH or N when “-----” is a bond, or, if “-----” is absent, U is CH 2, NH or NR ⁹; R ² is H, alkylcarbonyl or –CH 2 -R ³; R ³ is H, alkyl or hydroxyalkyl; R ⁴ is H or, if n is not 0 and R ⁵ is H, may also be OH; R ⁵ is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R ⁶ is hydroxyalkyl, carboxy, alkoxycarbonyl or -(CH 2 ) q -NR ⁷ R ⁸, q being 1, 2 or 3 and each of R ⁷ and R ⁸ independently being H or alkyl or R ⁷ and R ⁸ forming with the N atom bearing them a ring; R ⁹ is alkyl or hydroxyalkyl; A is -(CH 2 ) p -, -CH 2 CH 2 CH(OH)- or -COCH 2 CH(OH)-; G is substituted phenyl or G ¹ or G ², wherein Q is O or S and X is CH or N; and Y ¹, Y ² and Y 3 may each be CH or N; and n is 0 when A is -CH 2 CH 2 CH(OH)- or -COCH 2 CH(OH)-, and n is 0, 1 or 2 when A is -(CH 2 ) p -, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts of such compounds.