ANTIBODY MODULATING THE DIFFERENTIATION AND FUNCTION OF DENDRITIC CELLS VIA BINDING INTERCELULAR ADHESION MOLECULE-1 AND USE THEREOF

摘要

The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and prolong the graft survival. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.