摘要 |
<p>The present invention describes recovery and racemization of (1R)-Phenyl- 1,2,3,4-tetrahydroisoquinoline of compound of formula (III) to obtain racemic 1- phenyl-1, 2,3,4-tetrahydroisoquinoline of compound of formula (I) and its further resolution to get ( IS)-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (intermediate B) in high chemical and chiral purity, which is the key intermediate for the preparation of (3R)-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2-(1H)- carboxylate.</p> |
申请人 |
CADILA HEALTHCARE LIMITED;KOTHARI, HIMANSHU M.;DAVE, MAYANK GHANSHYAMBHAI;PANDEY, BIPIN |
发明人 |
KOTHARI, HIMANSHU M.;DAVE, MAYANK GHANSHYAMBHAI;PANDEY, BIPIN |