HYDROXY-SUBSTITUTED COLD(III) PORPHYRIN COMPLEXES AS HISTONE DEACETYLASE INHIBITORS

摘要

A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein:—R is selected from the group consisting of—OH,—CH2OH, C2H4OH,—C3H6OH or—C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.