发明名称 |
METHODS AND COMPOSITIONS FOR INCREASING THE ACTIVITY OF INHIBITORY RNA |
摘要 |
The invention provides methods for increasing the activity of an inhibitory RNA (RNAi) in a subject requiring administering one or more poly-ADP-ribose polymerase (PARP) inhibitors and/or one or more PARG activators to the subject. The invention also provides methods for increasing the activity of an inhibitory RNA in a cell or cell population requiring contacting a cell or cell population with one or more PARP inhibitors and/or one or more PARG activators. The invention further provides compositions and kits containing one or more PARP inhibitors and/or one or more PARG activators.
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申请公布号 |
US2011097328(A1) |
申请公布日期 |
2011.04.28 |
申请号 |
US20100821967 |
申请日期 |
2010.06.23 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
CHANG PAUL;LEUNG ANTHONY;SHARP PHILLIP A. |
分类号 |
A61K39/395;A61K31/7088;C12N5/02 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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