METHOD FOR PRODUCING CANCER STEM CELL

摘要

Mainly disclosed is a technique for artificially constructing a cancer stem cell from a cancer cell. A cancer cell is derived into a cancer stem cell having a self-renewal ability and acquiring an undifferentiation potency by introducing, into the cancer cell, (1) a KLF family gene, (2) an OCT family gene, (3) an SOX family gene, and (4) a gene of at least one kind of an undifferentiation-inducing factor selected from the group consisting of NANOG, LIN28, KRAS, BCL2, BMI1 and ERAS, and/or an expression inhibitor of at least one kind of a cancer suppressor gene selected from the group consisting of CDKN2A, FHIT, TP53, RB1, PTEN and LZTS1.