PROCESS FOR THE MANUFACTURE OF ENANTIOMERICALLY PURE ARYLOCTANOIC ACIDS AS ALISKIREN

摘要

The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, a novel bicyclic compound of formula IV.