<p>The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.</p>
申请公布号
WO2011050250(A1)
申请公布日期
2011.04.28
申请号
WO2010US53705
申请日期
2010.10.22
申请人
ON DEMAND THERAPEUTICS, INC.;HORNE, KENNETH, N.;SPOONER, GREGORY, J.R.;SCHOLL, JOHN, A.;SANTINI, JOHN, T. JR.
发明人
HORNE, KENNETH, N.;SPOONER, GREGORY, J.R.;SCHOLL, JOHN, A.;SANTINI, JOHN, T. JR.