发明名称 |
DERIVATIVES OF N-HYDROXYBENZAMIDE FOR TREATING HIV INFECTIONS |
摘要 |
Herein disclosed is a method for treating patients affected by HIV comprising administering N-hydroxy-benzamide-based histone deacetylase inhibitors, such as: diethyl-[6-(4-hydroxycarbamoyl-phenyl-carbamoyloxymethyl)-naphtalen-2-yl- methyl] -ammonium chloride; 4-(2-(S)-benzoylamino-3-naphtalen-2-yl-propionylamino)-N-hydroxy- benzamide; and/or benzo[l,3]dioxole-5-carboxylic acid [l(S)-(4-hydroxycarbamoyl- phenylcarbamoyl)-2-naphtalen-2-yl-ethyl]-amide. Such histone deacetylase inhibitors are administered in a dosage ranging from 50 to 200 mg/day, preferably from 100 to 200 mg/day, so as to obtain a blood concentration between 125 and 250 nM.
|
申请公布号 |
CA2773210(A1) |
申请公布日期 |
2011.04.28 |
申请号 |
CA20102773210 |
申请日期 |
2010.09.14 |
申请人 |
ITALFARMACO S.P.A. |
发明人 |
DINARELLO, CHARLES;FOSSATI, GIANLUCA;MASCAGNI, PAOLO |
分类号 |
A61K31/167;A61K31/36;A61K31/4245;A61K31/496;A61K31/536;A61K45/06;A61P31/18 |
主分类号 |
A61K31/167 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|