| 发明名称 |
COMPOSITIONS AND METHODS FOR DENDRITIC CELL-BASED IMMUNOTHERAPY |
| 摘要 |
<p>Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.</p> |
| 申请公布号 |
EP1272633(B1) |
申请公布日期 |
2011.04.27 |
| 申请号 |
EP20010920913 |
申请日期 |
2001.03.30 |
| 申请人 |
DENDREON CORPORATION |
发明人 |
LAUS, REINER;VIDOVIC, DAMIR;GRADDIS, THOMAS |
| 分类号 |
C12N5/06;C12N15/12;A61K35/12;A61K39/00;A61K39/385;A61P31/04;A61P31/10;A61P31/12;A61P33/00;A61P35/00;A61P37/04;C07K14/47;C07K14/535;C07K14/705;C07K14/71;C07K19/00;C12N5/07;C12N9/16;C12N15/27;C12N15/55;C12N15/62 |
主分类号 |
C12N5/06 |
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