| 摘要 |
<p>Producing (hetero)aryl compounds (A) and their diastereoisomers, comprises decarboxylative saponification of (hetero)aryl compounds (B1). Producing (hetero)aryl compounds (A) of formula (I)-(III) and their diastereoisomers, comprises decarboxylative saponification of (hetero)aryl compounds (B1) of formula (a)-(d). R1, R3 : C or CH; R2 : C=O or R10-C-R11, where one of R1-R2 and R2-R3 may be a C=C double bond; R10, R11 : H, lower 1-4C-alkyl when no double bond is present, or if a double bond is present one of R10 and R11 is absent; X : C (when R6 is =CH 2and R7 = CH 3), CR4, CH or COR5; R4 : H or lower alkyl; R5 : H, 1-16C-alkyl or protecting group; R6, R7 : CH 3, where at least one of R6 and R7 is CH 2=group and the other is CH 3; R8 : 1-16C-alkyl, H or a protecting group; R9 : 1-16C-linear or branched alkyl chain, or O-1-16C-linear or branched alkyl chain (where the alkyl chain is optionally contains one or more double or triple bond or substituents such as deuterium, halo, optionally substituted phenyl, cycloalkyl, CN, alkoxy or keto); R12 : CO 2-R13; and R13 : H, 1-16C-alkyl or a protecting group. [Image] [Image].</p> |
