6-modified bicyclic nucleic acid analogs

摘要

The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either ( R ) or ( S )-chirality at the 6-position. These bicyclic-nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.