发明名称 |
Cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid, useful as intermediate in the preparation of cannabinoid CB1 neutral antagonists |
摘要 |
<p>The present invention relates to a cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid. This cinchonidine salt is prepared by enantiomeric resolution of a compound of formula (I) comprising:
the reaction of compound of formula (I) with cinchonidine in a suitable solvent, thereby resulting in the cinchonidine salt of the enantiomer (4S,5S) of formula (II); and optionally isolating said salt. The cinchonidine salt according to formula (II) is a useful intermediate in the preparation of a cannabinoid CB 1 neutral antagonist.</p> |
申请公布号 |
EP2314578(A1) |
申请公布日期 |
2011.04.27 |
申请号 |
EP20090382203 |
申请日期 |
2009.10.13 |
申请人 |
ESTEVE QUIMICA, S.A. |
发明人 |
BARTRA SANMARTI, MARTI;BERENGUER MAIMO, RAMON;LLUIS TOUS, JORDI |
分类号 |
C07D401/06;C07D231/14;A61K31/415;A61P3/04 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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