| 摘要 |
<p>The present invention relates to a tailored pharmaceutical composition for use in treating a target disease in a patient, comprising two or more different antigens peptides, wherein at least one antigen peptide is derived from an antigen protein and at least a second antigen peptide is derived from a different antigen protein, both of said antigen proteins are related to the target disease in the patient, and the second antigen peptide is not included in the first antigen protein, wherein the antigen peptides have been selected by a method comprising the steps of (a) collecting peripheral blood mononuclear cells; (b) stimulating the collected peripheral blood mononuclear cells with antigen peptide candidates, said candidates being thought to be related to the target disease; (c) determining which antigen peptide candidate induced antigen-specific T cells; and (d) selecting two or more antigen peptide candidates which induced antigen-specific T cells as the antigen peptides to be administered to the patient; wherein the step of stimulating the peripheral blood mononuclear cells in process (b) is performed without directly using antigen presenting cells, and wherein the target disease cancer.</p> |
