发明名称 |
METHODS FOR THE TREATMENT OF PRIMARY HEADACHE DISORDERS USING PROSTANOID EP4 RECEPTOR ANTAGONISTS, AND ASSAYS FOR AGENTS FOR SUCH TREATMENT |
摘要 |
The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP4 receptor for prostaglandin E2. Particular EP4 receptor antagonists include azole compounds of formula (I) wherein R1 is a group such as a lower alkyl substituted with carboxy; R2 is hydrogen or lower alkyl, R3 and R4 are aryl optionally substituted with halogen, Q is formula (II) in which -A1- is a single bond or lower alkylene, Formula (III) is a cyclo group, -A3- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.
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申请公布号 |
CA2402099(C) |
申请公布日期 |
2011.04.26 |
申请号 |
CA20002402099 |
申请日期 |
2000.03.24 |
申请人 |
PHARMAGENE LABORATORIES LTD. |
发明人 |
BAXTER, GORDON SMITH;COLEMAN, ROBERT ALEXANDER;TILFORD, NICHOLAS |
分类号 |
A61K31/421;C07D263/32;A61K31/00;A61K31/352;A61K31/4174;A61K31/42;A61K31/426;A61K31/48;A61K31/5375;A61K45/00;A61P25/06;G01N33/68 |
主分类号 |
A61K31/421 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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