发明名称 |
Isoquinoline derivatives as calpain inhibitors |
摘要 |
The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid and (3-sec-butyl-1-thioxo-2, 3-dihydro-1H-isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease.
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申请公布号 |
US7932266(B2) |
申请公布日期 |
2011.04.26 |
申请号 |
US20050793011 |
申请日期 |
2005.12.05 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS |
发明人 |
HERRADON GARCIA BERNARDO;CHICHARRO MARTIN ROBERTO;ARAN REDO VICENTE JESUS;ALONSO GINER MERCEDES |
分类号 |
A61K31/44;C07D217/24 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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