QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON

摘要

PROBLEM TO BE SOLVED: To provide a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%, wherein the composition includes liquiflash particles and an excipient mass. SOLUTION: The composition includes: a directly compressible inorganic salt; a cellulose derivative or a combination of the directly compressible inorganic salt and the cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in a ratio such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. COPYRIGHT: (C)2011,JPO&INPIT