| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods for making statin, such as atorvastatin (LIPITOR (R)), rosuvastatin (CRESTOR (R)), fluvastatin (LESCOL (R)), related compounds, and their intermediates. <P>SOLUTION: The invention provides novel aldolases, nucleic acids encoding them, e.g., nucleic acids of a gene sequence comprising a specific sequence, or a polypeptide comprising an amino acid sequence of a specific sequence or an enzymatically active fragment thereof, and uses of them. <P>COPYRIGHT: (C)2011,JPO&INPIT |
