发明名称 GENERATION OF AN HLA-NEGATIVE OSTEOGENIC PRECURSOR CELL LINE
摘要 The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used, for example, in bone grafting procedures. The lack of HLA Class I expression in the cells of the mineralized three-dimensional bone constructs reduces or eliminates the potential for host-graft rejection.
申请公布号 US2011091862(A1) 申请公布日期 2011.04.21
申请号 US20080742831 申请日期 2008.11.13
申请人 OSTEOSPHERE, LLC 发明人 CLARKE MARK S.F.;BRINKER MARK;SUNDARESAN ALAMELU
分类号 C12N5/077 主分类号 C12N5/077
代理机构 代理人
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