PHOSPHORYLATION OF THE ESTROGEN RECEPTOR ALPHA SERINE 282 AS A MARKER FOR ENDOCRINE THERAPIES IN BREAST CANCER
摘要
The present invention provides diagnostic methods and markers based on the phosphorylation state of certain amino acid residues of estrogen receptor a. The invention relates to the phosphorylation of specific estrogen receptor alpha residues as a marker for susceptibility to chemotherapy. The invention specifically discloses the phosphorylation of serine 282 of the ER-alpha, as a diagnostic marker for breast cancer cells which are more responsive to hormone therapy than cells without the said phosphorylation.
申请公布号
WO2011044654(A1)
申请公布日期
2011.04.21
申请号
WO2009CA01888
申请日期
2009.12.22
申请人
MURPHY, LEIGH C.;NUGENT, ZOANN J.;WATSON, PETER H.;SKLIRIS, GEORGIOS P.
发明人
MURPHY, LEIGH C.;NUGENT, ZOANN J.;WATSON, PETER H.;SKLIRIS, GEORGIOS P.