PYRIDINE DERIVATIVE HAVING SUBSTITUTED HETERO RING AND SUBSTITUTED γ-GLUTAMYLAMINO GROUP, AND ANTI-FUNGAL AGENT COMPRISING SAME.

摘要

Disclosed is an anti-fungal agent which has an excellent anti-fungal activity and excellent physical properties, particularly excellent solubility in water and excellent safety performance.  Specifically disclosed is a compound represented by formula (I) or a salt thereof.  [In the formula, R¹ represents a hydrogen atom, a halogen atom, an amino group, R¹¹-NH- (wherein R¹¹ represents a C1-6 alkyl group, a hydroxy-C1-6-alkyl group, a C1-6-alkoxy-C1-6-alkyl group, or a C1-6 alkoxycarbonyl-C1-6-alkyl group), R¹²-(CO)-NH- [wherein R¹² represents a C1-6 alkyl group or a C1-6-alkoxy-C1-6-alkyl group], a C1-6 alkyl group, a hydroxy-C1-6-alkyl group, a cyano-C1-6-alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R² represents a group represented by formula (II); one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom; the ring A represents a 5- or 6-membered heteroaryl or benzene ring which may have one or two halogen atoms or C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S-, or -SCH2-; R³ represents a hydrogen atom, a halogen atom, or a C1-6 alkyl, C3-8 cycloalkyl, C6-10 aryl, 5- or 6-membered heteroaryl, or 5- or 6-membered non-aromatic heterocyclic group which may have one or two substituents independently selected from the substituent group α shown below; R⁴ represents a hydrogen atom, or a halogen atom; and R represents a hydrogen atom, or a C1-6 alkyl group which may be substituted by a dimethylamino group.] [Substituent group α] A halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, and a C2-6 alkynyl group.].