ANTIBODY THERAPEUTICS WITH LOCAL ACTIVITY IN THE DIGESTIVE TRACT
摘要
This invention provides methods and compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been shown to be necessary for clinical benefit following systemic administration of antibody. This invention further describes therapeutic compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been associated with adverse events and systemic immunosuppression following systemic administration of antibody.
申请公布号
WO2011047328(A1)
申请公布日期
2011.04.21
申请号
WO2010US52934
申请日期
2010.10.15
申请人
AVAXIA BIOLOGICS, INC.;FOX, BARBARA, S.;STAFFORD, DOUGLAS, C.