发明名称 |
TREATING NEUROTOXICITY ASSOCIATED WITH COMBINATIONS OF 5 - FU OR ITS PRODRUGS AND DPD INHIBITORS |
摘要 |
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme in both nervous and non-nervous tissues within the patient and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU generated from a prodrug is in substantial excess of DPD inhibitor in the patient. |
申请公布号 |
WO2011047195(A1) |
申请公布日期 |
2011.04.21 |
申请号 |
WO2010US52734 |
申请日期 |
2010.10.14 |
申请人 |
ADHEREX TECHNOLOGIES, INC.;SPECTOR, THOMAS |
发明人 |
SPECTOR, THOMAS |
分类号 |
A61K31/513;A61P35/00 |
主分类号 |
A61K31/513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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