COMPOSITIONS FOR TISSUE AUGMENTATION

摘要

Methods for making biomaterials for augmentation of hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component and a contrast agent. The first precursor component contains at least two nucleophilic groups, and the second precursor component comprises at least dipentaerythritol penta-acrylate. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).