Use of the FGF-2 and anosmin-1 proteins for predicting the histopathology of the lesions of a patient suffering from a central nervous system (CNS) demyelinating disease by means of the detection of the amount of said proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for ascertaining the histopathological characteristics of the lesions of a patient suffering from a CNS demyelinating disease and to a kit for implementing said method. Preferably, the CNS demyelinating disease is multiple sclerosis and the biological fluid is cerebrospinal fluid (CSF).
申请公布号
CA2773527(A1)
申请公布日期
2011.04.21
申请号
CA20102773527
申请日期
2010.09.07
申请人
FUNDACION HOSPITAL NACIONAL DE PARAPLEJICOS PARA LA INVESTIGACION Y LA I NTEGRACION (FUHNPAIIN)
发明人
DE CASTRO SOUBRIET, FERNANDO;CLEMENTE LOPEZ, DIEGO;ORTEGA MUNOZ, MARIA CRISTINA;ARENZANA SANAGERICO, FRANCISCO JAVIER