AMINO ACID SEQUENCES DIRECTED AGAINST DICKKOPF-1 AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH BONE LOSS AND/OR OSTEOLYTIC LESIONS

摘要

Amino acid sequences are provided that are directed against Dickkopf-1 (Dkk-1), as well as compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, compounds, constructs and/or polypeptides, and to uses of such amino acid sequences, compounds, constructs, polypeptides, and/or compositions, for prevention and/or treatment of diseases and disorders associated with bone loss and/or osteolytic lesions.