MODEL CELLS OF NEURODEGENERATIVE DISEASE, PROCESS FOR PRODUCTION OF SAME, AND USE OF SAME

摘要

Model cells of a neurodegenerative disease, which is produced by inserting a causative gene of the neurodegenerative disease into the genomes of human pluripotent stem cells; nerve cells which are differentiated/induced from the model cells; a process for producing the model cells, which is characterized by comprising introducing the causative gene into human pluripotent stem cells and inserting the gene into the genomes of the cells preferably in a site-specific manner; a process for producing nerve cells by differentiating/inducing the model cells into the nerve cells; and a method for screening for a prophylactic and/or therapeutic substance for a neurodegenerative disease or a causative and/or exacerbating substance of the neurodegenerative disease, which is characterized by comprising bringing the model cells or the nerve cells into contact with a substance to be tested and employing, as an indicator, the occurrence of improvement or deterioration in a pathological change of the neurodegenerative disease in the cells.