摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention describes ergoline derivatives of formula (I), in which each of R1 and R2 independently denotes H; optionally R10 and/or R11-substituted phenyl or -phenyl C1-C4alkyl; optionally R10 and/or R11-substituted heteroaryl or -heteroaryl C1-C4alkyl; optionally R10 and/or R11-substituted N-oxide heteroaryl; optionally R10-substituted C1-C8alkyl; optionally R10-substituted C2-C8alkenyl; optionally R10-substituted C2-C8alkynyl; optionally R10-substituted C3-C8cycloalkyl; or optionally R10-substituted C4-C8cycloalkenyl; or r1 and r2 together with the nitrogen atom to which they are bonded optionally form R10-substituted 3-8-member ring, which, in addition to the nitrogen atom, contains up to 2 heteroatoms independently selected from a group comprising N, O and S; R3 denotes H; OR1; CH2R1R2; (CH2)1-2NR1R2; CH2-CH2-OR1; CH2-CO-NR1R2; or CO-CH2R1R2; R4 denotes F; CI; Br; I; OR1, NR1R2 or assumes one of the values given for R1; and R5 assumes one of the values given for R1, in free form or in form of a salt for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands. ^ EFFECT: high effectiveness of the compounds. ^ 14 cl, 99 ex, 8 tbl |