发明名称 |
CONTROLLED RELEASE COPOLYMER FORMULATION WITH IMPROVED RELEASE KINETICS |
摘要 |
The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation within a patient's body tissues as a depot to release the agent over a period of time, wherein the copolymer provides a substantially constant rate of release of the bioactive agent over the time period for which the depot persists in the body tissues. The copolymer includes a PLG copolymer and a PLG oligomer of about 5-10 kDa average molecular weight, which can lack free carboxylic acid groups. When the PLG copolymer is a low burst copolymer, the constant release copolymer composition is a low burst, constant release copolymer composition adapted for implantation in the body tissues of a mammal, wherein a substantially constant rate of release of the bioactive agent is achieved. |
申请公布号 |
EP2309982(A2) |
申请公布日期 |
2011.04.20 |
申请号 |
EP20090758744 |
申请日期 |
2009.06.03 |
申请人 |
TOLMAR THERAPEUTICS, INC. |
发明人 |
NORTON, RICHARD, L.;DADEY, ERIC |
分类号 |
A61K9/06;A61K31/519;A61K38/09;A61K38/31;A61K47/10;A61K47/18;A61K47/20;A61K47/22;A61K47/34 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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