Fused bicyclic-substituted amines as histamine-3 receptor ligands

摘要

Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions. X is O, S, NH, or N(alkyl); Y, and Y' are each independently selected from the group consisting of CH, CF, and N; Z is C or N, provided that when X is O or S, Z is N; one of R 1 and R 2 is selected from the group consisting of aryl, heteroaryl, and heterocycle; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R 3 is absent when Z is N and, when present, R 3 is selected from the group consisting of hydrogen, methyl, alkoxy, halo and cyano; R 4 and R 5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, and cycloalkylalkyl, or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring L is -[C(R 15 )(R 16 )]n-; m is an integer from 0-3; and n is an integer from 2-3.
or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein:
X is O,S,NH,or N(alkyl);
Y, and Y' are each independently selected from the group consisting of CH, CF, and N;
Z is C or N, provided that when X is O or S, Z is N;
one of R 1 and R 2 is selected from the group consisting of aryl, hetereoaryl, and heterocycle.