发明名称 |
VACCINE STRAIN OF A/17/BRISBANE/07/1 (H3N2) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN |
摘要 |
FIELD: medicine. ^ SUBSTANCE: A/17/Brisbane/07/1 (H3N2) strain replicates actively in growing chicken embryos at optimum temperature 32C. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes coding internal non-glycosylated proteins have been inherited from an attenuation donor. The A/17/Brisbane/07/1 (H3N2) strain is areactogenic for adults and children in intranasal introduction. The invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the A/17/Brisbane/07/1 (H3N2) strain. ^ EFFECT: strain is characterised by thermal sensitivity and cold adaptation. ^ 1 dwg, 3 tbl |
申请公布号 |
RU2416640(C1) |
申请公布日期 |
2011.04.20 |
申请号 |
RU20100100524 |
申请日期 |
2010.01.11 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT EHKSPERIMENTAL'NOJ MEDITSINY SEVERO-ZAPADNOGO OTDELENIJA RAMN (NIIEHM SZO RAMN) |
发明人 |
KISELEVA IRINA VASIL'EVNA;LARIONOVA NATAL'JA VALENTINOVNA;RUDENKO LARISA GEORGIEVNA;ALEKSANDROVA GALINA IBRAGIMOVNA |
分类号 |
A61K39/145;C12N7/00 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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地址 |
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