发明名称 Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
摘要 Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.
申请公布号 EP2312315(A1) 申请公布日期 2011.04.20
申请号 EP20100187778 申请日期 2006.05.18
申请人 NOVARTIS AG;XOMA TECHNOLOGY LTD. 发明人 AUKERMAN, SHARON LEA;JALLAL, BAHIJA;LUQMAN, MOHAMMAD
分类号 G01N33/564;A61P37/00;G01N33/68 主分类号 G01N33/564
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