发明名称 |
BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS |
摘要 |
<p>The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.</p> |
申请公布号 |
EP2310373(A1) |
申请公布日期 |
2011.04.20 |
申请号 |
EP20090774475 |
申请日期 |
2009.07.01 |
申请人 |
GENENTECH, INC. |
发明人 |
HEALD, ROBERT, ANDREW;JACKSON, PHILIP;LYSSIKATOS, JOSEPH;PRICE, STEPHEN;SAVY, PASCAL, PIERRE |
分类号 |
C07D231/56;A61K31/437;A61P35/00;C07D275/04;C07D403/12;C07D405/12;C07D471/04 |
主分类号 |
C07D231/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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